Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder
نویسندگان
چکیده
منابع مشابه
P146: Gamma Aminobutyric Acid (GABA) and its Alterations in Stress
Gamma aminobutyrate (GABA) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. Mechanisms by which GABA may facilitate these responses to stress are metabolic and/or mechanical disruptions. Environmental stresses increase GABA accumulation through cytosolic acidification, induce an acidic pH-dependent activation of glutamate...
متن کاملGamma-Aminobutyric Acid (GABA) Monograpy
Introduction Gamma-aminobutyric acid (GABA) is a major neuro transmitter widely distributed throughout the central nervous system (CNS). Because too much excitation can lead to irritability, restlessness, insomnia, seizures, and movement disorders, it must be balanced with inhibition. GABA – the most important inhibitory neurotransmitter in the brain – provides this inhibition, acting like a “b...
متن کاملGamma-aminobutyric acid (GABA) in cerebrospinal fluid.
Levels of gamma-aminobutyric acid (GABA) in cerebrospinal fluid (CSF) were measured by radioreceptor assay (RRA) in 25 normal controls and in 121 patients with various central nervous system disorders. CSF-GABA levels could be measured down to 5 pmoles/ml reliably by this assay. In normal controls, the mean (+/- SEM) GABA level in CSF was 127 +/- 5.2 pmoles/ml. There was no correlation between ...
متن کاملp146: gamma aminobutyric acid (gaba) and its alterations in stress
gamma aminobutyrate (gaba) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. mechanisms by which gaba may facilitate these responses to stress are metabolic and/or mechanical disruptions. environmental stresses increase gaba accumulation through cytosolic acidification, induce an acidic ph-dependent activation of glutamate...
متن کاملgamma-Aminobutyric acid (GABA) and sepsis-related encephalopathy.
In order to determine whether disturbances in GABA homeostasis might play a role in the pathogenesis of sepsis-related encephalopathy, serum and brain tissue GABA concentrations from six areas of the brain (cortex, diencephalon, striatum, hippocampus, midbrain, and pons-medulla) were determined in a rat model of bacterial sepsis (cecal ligation and perforation). The results were compared to tho...
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ژورنال
عنوان ژورنال: Bipolar Disorders
سال: 2013
ISSN: 1398-5647
DOI: 10.1111/bdi.12074